Journal of Contemporary Dentistry

Register      Login

VOLUME 1 , ISSUE 2 ( October-December, 2011 ) > List of Articles


Infiltrative Type of Bone Invasion in Oral Squamous Cell Carcinoma – Case Report

Shwetha Kumar, Jigna Pathak

Citation Information : Kumar S, Pathak J. Infiltrative Type of Bone Invasion in Oral Squamous Cell Carcinoma – Case Report. J Contemp Dent 2011; 1 (2):49-52.

DOI: 10.5005/jcd-1-2-49

License: CC BY-ND 3.0

Published Online: 01-11-2003

Copyright Statement:  Copyright © 2011; The Author(s).


Oral squamous cell carcinoma (OSCC) is a well known malignancy which accounts for more than 90% of all oral cancers. OSCC are malignant tumors that frequently invade bone and bone invasion is a common clinical problem. Bone invasion by oral squamous cell carcinoma may progress by either an infiltrative or an erosive histological pattern. The pattern of bone invasion co-relates with the clinical behavior of OSCC thus having a potential prognostic value. The present case report is of a 35-year- old female patient presenting with a lesion in the lower right buccal vestibule which was histopathologically confirmed as OSCC. The type of bony invasion was also assessed microscopically. The objective of this paper was to define the characteristics associated with each histological pattern of invasion and its significance when reviewing oral squamous cell carcinoma with mandibular invasion.

PDF Share
  1. Molecular pathogenesis of oral squamous cell carcinoma: Implications for therapy. J Dent Res 2008:87;14-32.
  2. Patterns of mandibular invasion in oral squamous cell carcinoma of the mandibular region. World J Surg Oncol. 2007;5:12.
  3. Buccal mucosa, alveolus, retromolar trigone, floor of mouth, hard palate, and tongue tumors. In: Thawley SE, ed. Comprehensive Management of Head and Neck Tumors. II Ed. Philadelphia: WB Saunders; 1999:686-693.
  4. Keel SB, Glynn RJ,. Varvares MA. Histological Pattern of Mandibular Invasion by Oral Squamous Cell Carcinoma. The Laryngoscope. January 2000;110(1):65-72.
  5. Oral Oncology 2010;45:407-10
  6. MDCT and MRI in the evaluation of mandibular invasion by OSCC. Correlation with pathological data. Journal of Experimental & Clinical Cancer Research 2010, 29:73
  7. Effects of soluble factors released by OSCC on osteoclasts. M.Sc thesis February 2011, McGill University, Montreal, Canada.
  8. , Matsuo K., Tominaga K. Takahashi T., Nakanishi O. The cellular and molecular mechanisms of bone invasion by Oral Squamous Cell Carcinoma. Review article. Oral Diseases 2011;17:462-468.
  9. The role of tumor invasion into the mandible of oral squamous cell carcinoma. J Cancer Res Clin Oncol 2011;137:165-171.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.