Aim To evaluate and compare the shear bond strength of layered veneering porcelain and heat-pressed porcelain to laser-sintered cobalt–chromium alloy. Materials and methods Thirty disks of laser-sintered Co-Cr alloy of dimensions 10 × 4 mm were made and divided into two groups, I and II (n = 15). Metal alloy samples were veneered with porcelain to produce shear bond test samples: group I with conventionally layered porcelain (Ivoclar Vivadent IPS Inline) and group II with pressable porcelain (Ivoclar Vivadent IPS POM). The veneering porcelain, 4 mm in thickness, was either layered or pressed to its corresponding metal alloy samples. Firing of porcelains was carried out in particular furnaces for groups I and II. Shear bond strength testing was conducted in a universal testing machine, and the failure strengths were recorded. Fracture surfaces were characterized visually, under a stereomicroscope. For normality of data, Kolmogorov–Smirnov and Shapiro–Wilk tests were used and Levene's test for equality of variances and t-test for equality of means were also used. Frequencies of shear bond strengths were plotted using histogram and bar diagram. Results For group I samples, the mean (standard deviation) shear bond strength was 45.25 MPa and for group II, it was 60.11 MPa. There was a significant difference between groups I and II. Group II had a significantly higher shear bond strength value than group I (p = 0.012). For all shear bond strength testing samples in group I, cohesive, adhesive, and mixed failures were observed, and in group II, mostly adhesive and few mixed were observed. Conclusion Shear bond strength of heat-pressed porcelain to laser-sintered Co-Cr alloy was higher than shear bond strength of layered veneering porcelain to laser-sintered Co-Cr alloy. How to cite this article Pradhan SK, Nadgere JB, Ram SM. A Comparative Evaluation of Shear Bond Strength of Layered Veneering and Heat-pressed Porcelain to Laser-sintered Cobalt–Chromium Alloy: An in vitro Study. J Contemp Dent 2018;8(1):1-7.