Oral verrucous hyperplasia (OVH) is a slow growing, soft tissue premalignant lesion which can transform into oral cancer. Areca-nut and quid use do seem to have a significant influence on the appearance of oral verrucous hyperplasia. Most frequently observed sites are buccal mucosa and lateral border of the tongue. OVH begins as a white plaque of hyperkeratosis known as plaque type variant which can get further transformed into mass type with less keratinization, exophytic growth and proliferative features thus leading to malignant transformation and poorer prognosis. This article describes series of cases which have been diagnosed histopathologically as verrucous hyperplasia with its clinical presentation and histopathological variants along with the criteria elaborated by different authors in establishing a diagnosis and a brief overview of the treatment modalities.
Kallarakkal TG, Ramanathan A, Zain RB. Verrucous papillary lesions: Dilemmas in diagnosis and terminology. International journal of dentistry. 2013;2013.
Zain R, Kallarakkal T, Ramanathan A, Kim J, Tilakaratne WM, Takata T et al. Exophytic Verrucous Hyperplasia of the Oral Cavity – Application of Standardized Criteria for Diagnosis from a Consensus Report. Asian Pacific Journal of Cancer Prevention 2016;17(9):4491-4501
Patil S, Warnakulasuriya S, Raj T, Sanketh DS, Rao RS. Exophytic oral verrucous hyperplasia: a new entity. Journal of investigative and clinical dentistry. 2016 Nov;7(4):417-423.
Grover S, Jha M, Sharma B, Kapoor S, Mittal K, Parakkat NK, Shivappa AB, Kaur R. Verrucous Hyperplasia: Case report and differential diagnosis. Sultan Qaboos University Medical Journal. 2017 Feb;17(1):e98.
Shear M, Pindborg JJ Verrucous hyperplasia of the oral mucosa. Cancer. 1980;46:1855-1862.
Murrah VA, Batsakis JG. Proliferative verrucous leukoplakia and verrucous hyperplasia. Ann Otol Rhinol Laryngol. 1994;103:660-663.
Wang YP, Chen HM, Kuo RC, Yu CH, Sun A, Liu BY, Kuo YS, Chiang CP. Oral verrucous hyperplasia: histologic classification, prognosis, and clinical implications. Journal of Oral Pathology & Medicine. 2009 Sep;38(8):651-656.
Hazarey V, Ganvir S, Bodhade A. Verrucous hyperplasia: A clinico-pathological study. J Oral Maxillofac Pathol. 2011 May-Aug; 15(2): 187–191.
Slootweg PJ, Muller H. Verrucous hyperplasia or verrucous carcinoma: An analysis of 27 patients. J Maxillofac Surg. 1983;11(1):13-19.
Klieb H, Raphael SJ. Comparative study of the expression of P53, Ki67, E-cadherin and MMP-1 in verrucous hyperplasia and verrucous carcinoma of the oral cavity. Head Neck Pathol. 2007 Dec; 1(2):118-122.
Paral KM, Taxy JB, Lingen MW. CD34 and á smooth muscle actin distinguish verrucous hyperplasia from verrucous carcinoma. Oral surgery, oral medicine, oral pathology and oral radiology. 2014;117(4):477-482.
Chang Y, Yu C. Successful treatment of a large oral verrucous hyperplasia with photodynamic therapy combined with cryotherapy. Journal of Dental Sciences. 2013(8):87e90.