Journal of Contemporary Dentistry

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VOLUME 8 , ISSUE 3 ( September-December, 2018 ) > List of Articles


Oral Lichen Planus–A Brief Review on Treatment Modalities

Niharika Swain, Shilpa Patel, Jigna Pathak, Ketki J Shirke, Tanvi Patel, Mitesh N Jain

Keywords : Lichen planus, Management, Update

Citation Information : Swain N, Patel S, Pathak J, Shirke KJ, Patel T, Jain MN. Oral Lichen Planus–A Brief Review on Treatment Modalities. J Contemp Dent 2018; 8 (3):137-143.

DOI: 10.5005/jp-journals-10031-1238

License: CC BY-ND 3.0

Published Online: 01-12-2017

Copyright Statement:  Copyright © 2018; The Author(s).


Lichen planus is an autoimmune-mediated chronic inflammatory disease of unknown etiology, but studies have reported the role of cytotoxic T cells responsible for the disruption of basal keratinocytes and also causing the clinical symptoms. It is commonly seen in adults, with rare occurrence in children. It clinically manifests on the skin and oral mucosa, with skin lesions healing faster than the oral lesions. To obtain a diagnosis, a complete history and characteristic clinical features are usually sufficient for diagnosis, but there are certain other lesions like lichenoid reaction, contact sensitivity, white sponge nevus, pemphigoid and lupus erythematosus that show similar clinical characteristics, hence the need for histopathological evaluation using standard criteria given by Krutchkoff or World Health Organization (WHO). The treatment administered is always for eliminating symptoms and discomfort of the patients. A variety of pharmacological and natural alternatives have been used, along with frequent follow up visits in case of a tropic and erosive lichen planus. The purpose of this paper is to review the current trends in the management of oral lichen planus.

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  1. Patil S, Khandelwal S, Sinha N, Kaswan S, Tipu FR. Treatment modalities of oral lichen planus: An update. J Oral Diagn 2012;1:47-52.
  2. Andreasen JO. Oral lichen planus: I. A clinical evaluation of 115 cases. Oral Surgery, Oral Medicine, Oral Pathology. 1968 Jan 1;25(1):31-42.
  3. McCreary CE, McCartan BE. Clinical management of oral lichen planus. Br J Oral Maxillofac Surg 1999;37:338-343
  4. Jungell P. Oral lichen planus. A review. Int J Oral Maxillofac- Surg 1991;20:129-135
  5. Silverman S Jr. Lichen planus. Curr Opin Dent 1991;1:769-772
  6. Scully C, el-Kom M. Lichen planus: review and update on pathogenesis. J Oral Pathol Med 1985;14:431-458.
  7. Silverman S, Gorsky M, Lozada-Nur F: A prospective followup study of 570 patients with oral lichen planus: Persistence, remission, and malignant association. Oral Surg Oral Med Oral Patho 1985 Jul 1;60(1):30-34.
  8. Kramer IR, Lucas RB, Pindborg JJ, Sobin LH. Defi nition of leukoplakia and related lesions: An aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol 1978;46:518-539.
  9. Maher Hasan Aghbari et al in 2017 Malignant transformation of oral lichen planus and oral lichenoid lesions- A meta analysis of 20095 patient data
  10. Silverman S Jr. Oral lichen planus: A potentially premalignant lesion. J Oral Maxillofac Surg 2000;58:1286-1288
  11. Carrozzo M, Gandolfo S. The management of oral lichenplanus. Oral Dis 1999;5:196-205.
  12. Lozada-Nur F, Miranda C. Oral lichen planus: topical andsystemic therapy. Semin Cutan Med Surg 1997;16:295-300.
  13. Jainkittivong A, Kuvatanasuchati J, Pipattanagovit P, Sinheng W. Candida in oral lichen planus patients undergoing topical steroid therapy. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2007 Jul 1;104(1):61-66.
  14. Werneck JT, Costa TD, Stibich CA, Leite CA, Dias EP, Silva Junior A. Oral lichen planus: study of 21 cases. Anais brasileiros de dermatologia. 2015 Jun;90(3):321-326.
  15. Dreyer WP. The clinical manifestations of oral lichen planus. The Journal of the Dental Association of South Africa= Die Tydskrif van die Tandheelkundige Vereniging van Suid- Afrika. 1983 Oct;38(10):619-624.
  16. Sehgal VN, Abraham GJ, MALIK GB. Griseofulvin therapy in lichen planus: a double-blind controlled trial. British Journal of Dermatology. 1972 Oct;87(4):383-385.
  17. Lundstrom IM, Anneroth GB, Holmberg K. Candida in patients with oral lichen planus. International Journal of Oral and Maxillofacial Surgery. 1984 Jun 1;13(3):226-238.
  18. Carbone M, Conrotto D, Carrozzo M, Broccoletti R, Gandolfo S, Scully C. Topical corticosteroids in association with miconazole and chlorhexidine in the long-term management of atrophicerosive oral lichen planus: a placebo-controlled and comparative study between clobetasol and fluocinonide. Oral diseases. 1999 Jan;5(1):44-49.
  19. Marable DR, Bowers LM, Stout TL, Stewart CM, Berg KM, Sankar V, et al. Oral candi-diasis following steroid therapy for oral lichen planus. Oral diseases. 2016 Mar;22(2):140-147.
  20. Mostafa B, Zakaria M. Evaluation of Combined Topical Ozone and Steroid Therapy in Management of Oral Lichen Planus. Open access Macedonian journal of medical sciences. 2018 May 20;6(5):879-884.
  21. Patil S, Khandelwal S, Sinha N, Kaswan S, Rahman F, Tipu S. Treatment modalities of oral lichen planus: an update. Journal of Oral Diagnosis. 2016;1(1):01:e3
  22. Epstein JB, Truelove EL. Topical cyclosporine in a bioadhesive for treatment of oral lichenoid mucosal reactions: an open label clinical trial. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 1996 Nov 1;82(5):532-536.
  23. Eisen D, Carrozzo M, Bagan Sebastian JV, Thongprasom K. Number V Oral lichen planus: clinical features and management. Oral diseases. 2005 Nov;11(6):338-349.
  24. Thongprasom K, Chaimusig M, Korkij W, Sererat T, Luang jarmekorn L, et al. A randomized controlled trial to compare topical cyclosporin with triamcinolone ace-tonide for the treatment of oral lichen planus. Journal of oral pathology & medicine. 2007 Mar;36(3):142-146.
  25. Olejarz W, Bryk D, Zapolska-Downar D. Mycophenolate Mofetil A New Atheropreventive Drug?. Acta poloniae pharmaceutica. 2014 May;71(3):353-361.
  26. Wee JS, Shirlaw PJ, Challacombe SJ, Setterfield JF. Efficacy of mycophenolate mofetil in severe mucocutaneous lichen planus: a retrospective review of 10 patients. British Journal of Dermatology. 2012 Jul;167(1):36-43.
  27. Beck HI, Brandrup F. Treatment of erosive lichen planus with dapsone. Acta dermato-venereologica. 1986;66(4):366-367.
  28. Graham Jr WR. Adverse effects of dapsone. International journal of dermatology. 1975 Sep;14(7):494-500
  29. Aufdemorte TB, De Villez RL, Gieseker DR. Griseofulvin in the treatment of three cases of oral erosive lichen planus. Oral Surgery, Oral Medicine, Oral Pathology. 1983 May 1;55(5):459- 462.
  30. Honigsmann H, Wolff K, Fitzptrik TB. Oral photochemotherapy with psorolean and UVA Principles and practice in Dermatology in Genral Medicine. 3rd edition 1987;1533-1558.
  31. Ortonne JP, Thivolet J, Sannwald C. Oral photochemotherapy in the treatment of lichen planus (LP). Clinical results, histological and ultrastructural observations. Br J Dermatol. 1978 Jul;99(1):77-88.
  32. Lavanya N, Jayanthi P, Rao UK, Ranganathan K. Oral lichen planus: An update on pathogenesis and treatment. Journal of oral and maxillofacial pathology: JOMFP. 2011 May;15(2):127.
  33. Jori G, Fabris C, Soncin M, Ferro S, Coppellotti O, Dei D, Fantetti L. et al. Photodynamic therapy in the treatment of microbial infections: basic principles and perspective applications. Lasers Surg Med. 2006;38(5):468-481.
  34. Diana Mostafa, Bassel Tarakji. Photodynamic Therapy in Treatment of Oral Lichen Planus. J Clin Med Res. 2015 Jun;7(6):393-399.
  35. Borgia F, Giuffrida R, Caradonna E, Vaccaro M, Guarneri F, Cannavo S. Early and late onset side effects of photodynamic therapy. Biomedicines. 2018 Mar;6(1):12.
  36. Jajarm HH, Falaki F, Mahdavi O. A comparative pilot study of low intensity laser versus topical corticosteroids in the treatment of erosive-atrophic oral lichen planus. Photomedicine and laser surgery. 2011 Jun 1;29(6):421-425.
  37. Clinton SK. Lycopene: chemistry, biology, and implications for human health and disease. Nutrition reviews. 1998 Feb 1;56(2):35-51.
  38. Saawarn N, Shashikanth MC, Saawarn S, Jirge V, Chaitanya NC, Pinakapani R. Lycopene in the management of oral lichen planus: a placebo-controlled study. Indian Journal of Dental Research. 2011 Sep 1;22(5):639-643.
  39. Keshari D, Patil K, Mahima VG. Efficacy of topical curcumin in the management of oral lichen planus: A randomized controlled-trial. J Adv Clin Res Insights. 2015;2:197- 203.
  40. Amirchaghmaghi M, Pakfetrat A, Delavarian Z, Ghalavani H, Ghazi A. Evaluation of the Efficacy of Curcumin in the Treatment of Oral Lichen Planus: A Randomized Controlled Trial. Journal of clinical and diagnostic research: JCDR. 2016 May;10(5):ZC134-ZC137.
  41. Prasad S, Solanki S, Chinmaya BR, Tandon S, Ashwini B. The magic of herbal curcumin therapy in recurrent oral lichen planus. Am J Ethnomed. 2014;1:96-101.
  42. Reddy RL, Reddy RS, Ramesh T, Singh TR, Swapna LA, Laxmi NV. Randomized trial of aloe vera gel vs triamcinolone acetonide ointment in the treatment of oral lichen planus. Quintessence international. 2012 Oct 1;43(9).
  43. Zhang J, Zhou G. Green tea consumption: an alternative approach to managing oral lichen planus. Inflammation Research. 2012 Jun 1;61(6):535-539.
  44. Preda EG, Pasetti P, Caggiula S, Nidoli G, Boggio E, Azzi R. Oral pathology of pscyhosomatic origin. Review of the literature. Dental Cadmos. 1990 Jan;58(1):66-72.
  45. Akay A, Pekcanlar A, Bozdag KE, Altintas L, Karaman A. Assessment of depression in subjects with psoriasis vulgaris and lichen planus. Journal of the European Academy of Derma-tology and Venereology. 2002 Jul;16(4):347-352.
  46. Rojo-Moreno J, Bagan J, Rojo-Moreno J, Donat JS, Milian MA, Jimenez Y. Psychologic factors and oral lichen planus: a psychometric evaluation of 100 cases. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontology. 1998 Dec 1;86(6):687-691.
  47. Radwan-Oczko M, Zwyrtek E, Owczarek JE, Szcze.niak D. Psychopathological profile and quality of life of patients with oral lichen planus. Journal of Applied Oral Science. 2018; 26.
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