Journal of Contemporary Dentistry

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VOLUME 8 , ISSUE 2 ( May-August, 2018 ) > List of Articles


Immunohistochemical Markers in Benign Odontogenic Tumors

Rashmi Hosalkar, Shraddha S Walekar, Shrikant R Sonune, Janaki S Iyer, Yogita Murudkar

Keywords : Ameloblastoma, Amelogenin, Cytokeratin, Immunohistochemical markers, Odontogenic tumors

Citation Information : Hosalkar R, Walekar SS, Sonune SR, Iyer JS, Murudkar Y. Immunohistochemical Markers in Benign Odontogenic Tumors. J Contemp Dent 2018; 8 (2):101-105.

DOI: 10.5005/jp-journals-10031-1231

License: CC BY-ND 3.0

Published Online: 01-03-2018

Copyright Statement:  Copyright © 2018; The Author(s).


Odontogenic tumours includes broad spectrum of lesions derived from specialized dental tissues. Neoplasms and tumours related to the odontogenic apparatus may be composed only of epithelial tissue or epithelial tissue associated with odontogenic ectomesenchyme. They constitute abortive attempt at odontogenesis. Odontogenic tumors can be intraosseous or extraosseous with varying clinical and radiographic features. Odontogenic tumours are associated with molecular and genetic alterations. This review presents outline of molecular and genetic alterations associated with nature and growth of benign odontogenic tumours.

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  1. Tumor Markers. National Cancer Institute (U S National Institutes of Health) 2006 Availablefrom: URL:
  2. Makretsov NA, Hayes M, Carter BA, Dabiri S, Gilks CB, Huntsman DG. Stromal CD10 expression in invasive breast carcinoma correlates with poor prognosis, estrogen receptor negativity, and high grade. Mod Pathol 2007; 20:84.89.
  3. Moradian. Oldak J, Du C, Falini G. On the formation of amelogenin microribbons. Eur J Oral Sci 2006; 114 Suppl 1:289.296.
  4. Deutsch D, Haze. Filderman A, Blumenfeld A, Dafni L, Leiser Y, Shay B, et al. Amelogenin, a major structural protein in mineralizing enamel, isalso expressed in soft tissues: Brain and cells of the hematopoietic system. Eur J Oral Sci 2006; 114 Suppl 1:183.189.
  5. Anigol, et al.: Amelogenin in odontogenic Cysts and tumours: An immunohistochemical study. National Journal of Maxillofacial Surgery 2014;5(2): 172.
  6. Gao Z et al. Patterns of keratin-expression in rests of Malassez and periapical lesions. J Oral Pathol 1988; 17: 178.185.
  7. MM Crivelini, VC de Araú jo, SOM de Sousa, NS de Araú jo. Cytokeratins in epithelia of odontogenic neoplasms. Oral Diseases 2003;9:1-6.
  8. Chiquet-Ehrismann R, Mackie EJ, Pearson CA, Sakakura T. Tenascin: an extracellular matrix protein involved in tissue interaction during fetal development and oncogenesis. Cell. 1986 Oct 10;47(1):131-139.
  9. Chiquet-Ehrismann R, Mackie EJ, Pearson CA, Sakakura T. Tenascin: an extracellular matrix protein involved in tissue interaction during fetal development and oncogenesis. Cell 1986;47:131-139.
  10. Heikinheimo K, Morgan PR, Happonen RP, Stenmann G, Virtanen I. Distribution of extracellular matrix proteins in odontogenic tumours and developing teeth. Virchows Archiv B Cell Pathol 199;61:101-109.
  11. Thesleff I, Mackie E, Vainio S, Ehrismann RC. Changes in the distributionof tenascin during tooth development. Development 1987;101:289-296.
  12. Rosen V Cox K. Hatterslev G. Bone morphogenetic protein. In Bilezikian JP, RA!SZ LG, Rodan Ga, eds. Principles of bone biology. San Diego. California: Academic Press. 1996:661-672.
  13. Vainio S, Karavanova I, Jowett A et al. Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 1993;75: 45-58.
  14. Gao YH, Yang LJ, Yamaguchi A;Imtnunohistochemical demonstration of bone Morphogenetic protein m odontogenictumors. J Oral Pathol Med 1997;26;273-277.
  15. Lemer UH. New molecules in the tumour necrosis factor ligand and receptor superfamilies with importance for physiologic and pathological boneresorption. Crit Rev Oral Biol Med 2004;15:64-81.
  16. Andrade FR, Sousa DP, Mendonca EF, Silva TA, Lara VS, Batista AC. Expression of bone resorption regulators (RANK, RANKL, and OPG) in odontogenictumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106(4):548-55.
  17. Boyce BF, Xing L. The RANKL/RANK/OPG pathway. Curr Osteoporos Rep. 2007 Sep; 5(3):98-104.
  18. Sorsa T, Tjaderhane L, Salo T. Matrix metalloproteinases (MMPs) in oral diseases. Oral Dis.2004 Nov;10(6):311-318.
  19. Brian T. Bast, M. Anthony Pogrel, Joseph A. Regezi, The Expression of Apoptotic Proteins and Matrix Metalloproteinases in Odontogenic Myxomas. J Oral Maxillofac-Surg 2003;61:1463-1466.
  20. Pinheiro JJV, Freitas VM, Moretti AIS, Jorge AG, Jaeger RG. Local invasiveness of ameloblastoma. Role played by matrix metalloproteinases and proliferative activity. Histopathology [Internet]. Wiley; 2004 Jul;45(1):65.72.
  21. Hudson BG, Reeders ST, Tryggvason K. Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis. J Biol Chem 1993 Dec 15;268(35) 26033-26036.
  22. Nagatsuka H, Siar C, Nakano K, Tsujigiwa H, Gunduz M, Choufuku H, et al. Differential expression of collagen IV 1 to 6 chains in basement membranes of benign and malignant odontogenic tumors. Virchows Archiv [Internet]. Springer Nature; 2002 Oct 1;441(4):392.399
  23. About I, Laurent-Maquin D, Lendahl U, Mitsiadis TA. Nestin Expression in Embryonic and Adult Human Teeth under Normal and Pathological Conditions. The American Journal of Pathology [Internet]. Elsevier BV; 2000 Jul;157(1):287.295.
  24. Fujita S. Nestin expression in odontoblasts and odontogenic ectomesenchymal tissue of odontogenic tumours. Journal of Clinical Pathology BMJ; 2006 Mar 1;59(3):240.245.
  25. Tsujimoto Y. Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria? Genes to Cells. 1998 Nov;3(11):697. 707.
  26. Kumamoto H, Ooya K. Immunohistochemical analysis of bcl-2 family proteins in benign and malignant ameloblastomas. Journal of Oral Pathology & Medicine. 2007 Feb 27;28(8):343.349.
  27. Alaeddini M, Etemad-Moghadam S, Baghaii F. Comparative expression of calretinin in selected odontogenic tumours: a possible relationship to histogenesis. Histopathology 2008 Feb;52(3):299.304.
  28. Al-Otaibi O, Khounganian R, Anil S, Rajendran R. Syndecan-1 (CD 138) surface expression marks cell type and differentiation in ameloblastoma, keratocystic odontogenic tumor, and dentigerous cyst. Journal of Oral Pathology & Medicine. 2012 Jul 2;42(2):186.193.
  29. Gültekin SE, Sengüven B, Aziz R, Heydt C, Buettner R. Molecular Profiling of Odontogenic Tumors - Pilot Study. Balkan Journal of Dental Medicine. 2017 Jul 26;21(2):112.115.
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